miércoles, 25 de febrero de 2015
lunes, 23 de febrero de 2015
domingo, 22 de febrero de 2015
La epidemiología clínica es el sustento de...
...lo invito a disfrutar este clásico.
Referencia:
Sackett DL. Clinical epidemiology. what, who, and whither. J Clin Epidemiol. 2002; 55(12):1161-6.
Referencia:
Sackett DL. Clinical epidemiology. what, who, and whither. J Clin Epidemiol. 2002; 55(12):1161-6.
Inflación de efectos por...
...inadecuado ocultamiento de la secuencia de la aleatorización.
Referencia:
Referencia:
Schulz
KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of
methodological quality associated with estimates of treatment effects in
controlled trials. JAMA. 1995; 273(5):408-12.
El riesgo médico
Referencia:
Bogardus ST Jr, Holmboe E, Jekel JF. Perils, pitfalls, and possibilities in talking about medical risk. JAMA. 1999;281(11):1037-41.
Bogardus ST Jr, Holmboe E, Jekel JF. Perils, pitfalls, and possibilities in talking about medical risk. JAMA. 1999;281(11):1037-41.
sábado, 21 de febrero de 2015
No solo el beneficio clínico...
... me interesan los perjuicios de la medicación. ¡<>!
Referencia:
Referencia:
Mahady SE, Schlub T, Bero L, Moher D, Tovey D,
George J, et al. Side effects are incompletely reported among systematicreviews in gastroenterology. J Clin Epidemiol. 2015; 68(2):144-53.
viernes, 20 de febrero de 2015
<<...basada en la mejor evidencia disponible>>...
... no es sinónimo de evidencia sólida.
Referencias:
Referencias:
1. Brok J, Thorlund K, Gluud C, Wetterslev J. Trial
sequential analysis reveals insufficient information size and potentially false
positive results in many meta-analyses. Journal of Clinical Epidemiology 2008;
61:763-769.
2. Brok J, Thorlund K, Wetterslev J, Gluud C.
Apparently conclusive meta-analyses may be inconclusive - Trial sequential
analysis adjustment of random error risk due to repetitive testing of
accumulating data in apparently conclusive neonatal meta-analyses.
International Journal of Epidemiology 2009; 38:287-298.
3. Thorlund
K, Devereaux PJ, Wetterslev J, Guyatt G, Ioannidis JP, Thabane L, et al. Can
trial sequential monitoring boundaries reduce spurious inferences from
meta-analyses? International Journal of Epidemiology 2009; 38:276-286.
4. Thorlund
K, Imberger G, Walsh M, Chu
R, Gluud C, Wetterslev
J, et al. The number
of patients and events required to limit the risk of overestimation of
intervention effects in meta-analysis- a simulation study. PLoS One. 2011;
6(10):e25491.
5. Wetterslev J, Thorlund K,
Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is
reached in cumulative meta-analysis. Journal of Clinical Epidemiology
2008;61:64-75.
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