¿Quiere cambiar el sistema de salud?

Inicie con una revisión sistemática.

Referencia: 

 

Dickersin K. Health-care policy. To reform U.S. health care, start with systematic reviews. Science. 2010;329(5991):516-7. PMID: 20671173

Para entender lo qué es evidencia y la importancia de...

...la revisión Cochrane. 

Referencia: 

MacQueen G.What does it mean to have enough evidence?. J Psychiatry Neurosci. 2013 Jan;38(1):3-5. 

PMID: 23249756

Cuando quieras...

 

...incursionar en ensayos clínicos o aprobar el protocolo ad hoc, date un 'paseíto' por aquí.

 

Referencias Bibliográfica:

 

1.- Chan AW, Tetzlaff JM, Gøtzsche PC, Altman DG, Mann H, Berlin JA, Dickersin K, Hróbjartsson A, Schulz KF, Parulekar WR, Krleza-Jeric K, Laupacis A, Moher D. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013 Jan 8;346:e7586. doi: 10.1136/bmj.e7586. PMID: 23303884

2.- Chan AW, Tetzlaff JM, Altman DG, Laupacis A, Gøtzsche PC, Krleža-Jerić K, Hróbjartsson A, Mann H, Dickersin K, Berlin JA, Doré CJ, Parulekar WR, Summerskill WS, Groves T, Schulz KF, Sox HC, Rockhold FW, Rennie D, Moher D. SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials. Ann Intern Med. 2013 Feb 5;158(3):200-7. doi: 10.7326/0003-4819-158-3-201302050-00583.
PMID: 23295957

 

 

 

No sobreestime...

... el riesgo con baja incidencia de eventos y con un tamaño de muestra liliputiense.

Referencia:

Thorlund K, Imberger G, Walsh M, Chu R, Gluud C, Wetterslev J, Guyatt G, Devereaux PJ, Thabane L. The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study. PLoS One. 2011;6(10):e25491. doi: 10.1371/journal.pone.0025491. Epub 2011 Oct 18.

¿Pocos eventos, pocos estudios? ¡Cuidado!

... con la interpretación de la heterogeneidad del meta-análisis.

 Referencia:

Thorlund K, Imberger G, Johnston BC, Walsh M, Awad T, Thabane L, Gluud C, Devereaux PJ, Wetterslev J. Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses. PLoS One. 2012;7(7):e39471. PMID: 22848355

 

La alegría del sudor de 2012

Antibiotics for treating osteomyelitis in people with sickle cell disease.

Martí-Carvajal AJ, Agreda-Pérez LH.

Cochrane Database Syst Rev. 2012 Dec 12;12:CD007175. doi: 10.1002/14651858.CD007175.pub3.

PMID: 23235640

Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients.

Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF.

Cochrane Database Syst Rev. 2012 Dec 12;12:CD004388. doi: 10.1002/14651858.CD004388.pub6.

PMID: 23235609

3.

Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy.

Hidalgo R, Martí-Carvajal AJ, Kwong JS, Simancas-Racines D, Nicola S.

Cochrane Database Syst Rev. 2012 Nov 14;11:CD009077. doi: 10.1002/14651858.CD009077.pub2.

PMID:23152267

4.

Interventions for treating leg ulcers in people with sickle cell disease.

Martí-Carvajal AJ, Knight-Madden JM, Martinez-Zapata MJ.

Cochrane Database Syst Rev. 2012 Nov 14;11:CD008394. doi: 10.1002/14651858.CD008394.pub2.

PMID: 23152256

5.

Autologous platelet-rich plasma for treating chronic wounds.

Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, Garcia J.

Cochrane Database Syst Rev. 2012 Oct 17;10:CD006899. doi: 10.1002/14651858.CD006899.pub2. Review.

PMID: 23076929

6.

Antibiotics for treating community acquired pneumonia in people with sickle cell disease.

Martí-Carvajal AJ, Conterno LO.

Cochrane Database Syst Rev. 2012 Oct 17;10:CD005598. doi: 10.1002/14651858.CD005598.pub3. Review.

PMID: 23076916

7.

Antifibrinolytic amino acids for upper gastrointestinal bleeding in patients with acute or chronic liver disease.

Martí-Carvajal AJ, Solà I, Martí-Carvajal PI.

Cochrane Database Syst Rev. 2012 Sep 12;9:CD006007. doi: 10.1002/14651858.CD006007.pub3. Review.

PMID: 22972089

8.

Vitamin K for upper gastrointestinal bleeding in patients with acute or chronic liver diseases.

Martí-Carvajal AJ, Solà I.

Cochrane Database Syst Rev. 2012 Sep 12;9:CD004792. doi: 10.1002/14651858.CD004792.pub4. Review.

PMID: 22972075

9.

Treatment for avascular necrosis of bone in people with sickle cell disease.

Martí-Carvajal AJ, Solà I, Agreda-Pérez LH.

Cochrane Database Syst Rev. 2012 May 16;5:CD004344. doi: 10.1002/14651858.CD004344.pub4. Review.

PMID: 22592696

10.

Human recombinant activated factor VII for upper gastrointestinal bleeding in patients with liver diseases.

Martí-Carvajal AJ, Karakitsiou DE, Salanti G.

Cochrane Database Syst Rev. 2012 Mar 14;3:CD004887. doi: 10.1002/14651858.CD004887.pub3. Review.

PMID: 22419301

11.

Human recombinant activated protein C for severe sepsis.

Martí-Carvajal AJ, Solà I, Lathyris D, Cardona AF.

Cochrane Database Syst Rev. 2012 Mar 14;3:CD004388. doi: 10.1002/14651858.CD004388.pub5. Review.

PMID: 22419295

Eficacia versus efectividad en ensayos clínicos aleatorizados

Comience por aquí... sólo, es una sugerencia.

Está en texto completo y gratis. 

Referencia:

Sackett DL. Exp Pol Arch Med Wewn. 2011;121(7-8):259-63. Explanatory and pragmatic clinical trials: a primer and application to a recent asthma trial. PMID: 21878863