Falla porque adolece en varios aspectos del diseño. A guisa de estimulo, por 'Insufficient Consideration of Prior Existing and Ongoing Evidence'.
Referencia:
Naci H, Ioannidis JP. How Good Is "Evidence" from Clinical Studies of Drug Effects and Why Might Such Evidence Fail in the Prediction of the Clinical Utility of Drugs? Annu Rev Pharmacol Toxicol. 2014 Aug 21. [Epub ahead of print].
PMID:
25149917
Naci H, Ioannidis JP. How Good Is "Evidence" from Clinical Studies of Drug Effects and Why Might Such Evidence Fail in the Prediction of the Clinical Utility of Drugs? Annu Rev Pharmacol Toxicol. 2014 Aug 21. [Epub ahead of print].
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